Knox County is a county located in Appalachia near the southeastern corner of the U.S. state of Kentucky. As of the 2020 census, the population was 30,193. Its county seat is Barbourville. The county is named for General Henry Knox. It is one of the few coal-producing counties in Kentucky that has not suffered massive population loss. Knox Count…Knox County is a county located in Appalachia near the southeastern corner of the U.S. state of Kentucky. As of the 2020 census, the population was 30,193. Its county seat is Barbourville. The county is named for General Henry Knox. It is one of the few coal-producing counties in Kentucky that has not suffered massive population loss. Knox County is included in the Corbin, KY Micropolitan Statistical Area.
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