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CRISPR system variant shows a novel DNA cleavage mechanism
The CRISPR-Cas5-HNH/Cascade complex, which serves as an immune defense system in prokaryotes ... replacing the need for Cas3, a protein commonly involved in DNA degradation in other systems.
The Scientist1y
Engineering the Microbiome: CRISPR Leads the Way
9 After characterizing CRISPR’s role as a defense mechanism in bacteria, researchers soon realized that they could harness this system for gene manipulation in any cell. All they needed to do was ...
Nature4y
Improved gene-editing precision to boost Japan’s bioeconomy
Typical guide RNAs are about 20 nucleotides long for CRISPR-Cas9 tools, but the TiD system typically uses 35 ... such as Cas9, Cpf1, and Cas3. However, unlike other CRISPR systems, TiD’s ...
manilatimes24d
SNIPR Biome Strengthens IP Portfolio with Patent Granted for a Novel CRISPR-Cas System
today announces grant of patent EP4392563B on February 24 th 2025 by the European Patent Office protecting the newly-discovered and characterised CRISPR-CasS ™ system. This system and its uses do not ...