A Ph.D. student in biomolecular engineering at the University of California, Santa Cruz, has built a software program ...

A team of CiRA researchers has uncovered the crucial role of EIF3D—a protein translational regulator—in primed pluripotency. The research is published in the journal Science Advances.

The CRISPR gene-editing tool was developed 10 years ago and has since been transformative for research. Here's what to know.

The format of the CRISPR screen, which is how the gRNA molecules are delivered to the cells, is also selected, as well as the CRISPR nuclease and gRNA molecules themselves.

The art of a good CRISPR screen involves selecting the appropriate tool(s) for the appropriate cellular context ...

A CRISPR-based loss-of-function screen has identified host genes that are needed for SARS-CoV-2 to infect human lung cells, pointing to potential novel treatment targets for COVID-19. SARS-CoV-2 ...

The Rathmell group is using the CRISPR-based screen Sugiura developed to explore multiple sets of genes in various disease models and is working to build a core resource for other Vanderbilt ...

Zebrafish, unlike people, can recover from spinal cord injuries, thanks to a healing process that’s controlled by immune cells called macrophages.

“In the CRISPR screen, we used human liver cells and knocked out every gene in the genome—about 19,000 genes—one at a time. We then stimulated the cells with interferon, knowing that this ...

CRISPR Screen Detects Functional Gene Regulation A CRISPR-Cas9–based method probes the regulatory roles of noncoding DNA sequences.