Watch the best plays from San Francisco 49ers running back Christian McCaffery's 142-yard game against the Carolina Panthers ...

San Francisco 49ers RB Christian McCaffrey rushed and caught for 121 yards, scoring three touchdowns in the team's Week 11 win over the Arizona Cardinals.

San Francisco QB Brock Purdy delivered a 9-yard touchdown pass to RB Christian McCaffrey in the team's Week 11 matchup against the Cardinals.

San Francisco 49ers running back Christian McCaffrey takes the toss and bursts into the end zone for a 12-yard touchdown run ...

Christian McCaffrey battles his former team in primetime as the 49ers face the Panthers in the Week 12 finale.

San Francisco's 41-year drought in Cleveland is over after the 49ers routed the Browns 26-8 to improve to 9-4 this season.

The San Francisco 49ers defense locked down the Carolina Panthers and the offense was able to overcome three first half ...

McCaffrey played great on Sunday, but he highlighted another running back after the 49ers’ win. Christian McCaffrey had 201 combined rushing and receiving yards in a win against the Falcons. McCaffrey ...

Christian McCaffrey remains extremely productive for the San Francisco 49ers in his age-29 season, and in at least one way, ...

The Houston Texans, in the midst of their Week 8 win over the San Francisco 49ers, 26-15, the Texans defense wound up holding star running back Christian McCaffrey to his quietest outing of an ...

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since ...