Concurrent analysis of whole-genome DNA methylation and single-cell RNA sequencing data from COVID-19 patients and controls reveals gene regulatory alterations in airway epithelial and immune cells.
Not all genes are active at all times. DNA methylation is one of several epigenetic mechanisms that cells use to control gene expression. This straightforward experiment demonstrated that it was ...
DNA methylation is a fundamental epigenetic mechanism in which a methyl group is added onto a nucleotide, commonly cytosine. DNA methylation affects many biological processes, including gene ...
However, there are certain hurdles to overcome. One significant challenge is the technical challenges in methylation analysis. The biggest problem for DNA methylation is diversity among cells produced ...
The researchers examined 850,000 sites of DNA methylation, where small chemical tags called methyl groups are added to DNA. This process can alter gene expression without changing the underlying ...