Kitty Dukakis, the former first lady of Massachusetts and the outspoken wife of 1988 Democratic presidential nominee Michael Dukakis, has died, her family said. She was 88 years old.Dukakis died on Friday night surrounded by her family,

She was a leader in the effort to ensure that the Holocaust is never forgotten, and an advocate for children, women and refugees.

Married to Gov. Michael Dukakis of Massachusetts, she became a proponent of electroshock therapy after unsuccessful treatments for alcoholism and depression.