Leptin receptor (LepR) expression varies significantly between these neuron types. AGRP/NPY neurons, when lacking LepR, lead ...

who have normal genes for leptin and its receptor, are leptin resistant. Despite extensive efforts in many laboratories, it remains unclear why ordinary obese people become resistant to their own ...

Here, we investigated the expression of leptin in stomach biopsies ... leptin-deficient ob/ob mice and intestine-specific leptin receptor isoform B-deficient mice. These data demonstrate that ...

"Currently, the only FDA-approved treatment for obesity due to leptin receptor deficiency is a daily injection. PL7737's oral form could provide a more convenient and effective option for these ...