Nature

Non-Syndromic Deafness Associated with a Mutation and a Polymorphism in the Mitochondrial 12S Ribosomal RNA Gene in a Large Zairean Pedigree

Hereditary non-syndromic deafness has been associated with a point mutation in the mitochondrial 12S rRNA gene. We present data from deaf individuals in 12 nuclear families originating from a small ...
The American Journal of Managed Care

IPF Progression Insights From Telomere Mutations, MUC5B Polymorphism: Ayodeji Adegunsoye, MD, PhD, MSc

Ayodeji Adegunsoye, MD, PhD, MSc, discusses how emerging genetic insights like telomere-related mutations may reshape disease management in idiopathic pulmonary fibrosis (IPF). These markers not only ...
The Scientist

The Mutation Sensation: Cleavase Fragment Length Polymorphism from Third Wave Technologies

p53 GENE MUTTION: Exons 5 and 6 of the p53 gene of five individuals were amplified and examined by Cleavase® Fragment Length Polymorphism (CFLP®) Analysis. The pattern marked "WT" is from an ...
GEN

SNP-Chip: CRISPR-Based Transistor Detects Single Point Mutations

Long before the COVID-19 pandemic shined a spotlight on CRISPR-based diagnostics, Kiana Aran, PhD, was developing the CRISPR-Chip. It was, according to Aran, the first transistor that uses CRISPR to ...
EurekAlert!

CRISPR-SNP-chip enables amplification-free electronic detection of single point mutations

video: Keck Graduate Institute (KGI) Assistant Professor and University of California, Berkeley Visiting Scientist Dr. Kiana Aran first introduced the CRISPR-Chip technology in 2019. Now just two ...
ascopubs.org

Molecular analysis of KRAS polymorphism mutation using a high-resolution melting system in a large mCRC patients sample in Mexico.

Hepatic arterial infusion (HAI) of oxaliplatin with either LV5FU2 or FOLFIRI in patients (pts) with refractory metastatic colorectal cancer (mCRC). This is an ASCO Meeting Abstract from the 2011 ASCO ...
Business Wire

CRISPR-SNP-Chip: Electronic Measurements of Single Nucleotide Polymorphisms Without DNA Amplification

SAN DIEGO--(BUSINESS WIRE)--Cardea Bio, a Tech+Bio company integrating molecular biology with semiconductors electronics via graphene-based biology-gated Cardean Transistors, announced today that its ...
ascopubs.org

CYP1A1*2A polymorphism as a prognostic factor for the advanced lung cancer patients treated with EGFR-TKI and its correlation with EGFR mutation.

Phase I study of elisidepsin (E) in combination with carboplatin (C) in patients (pts) with advanced solid tumors. Progression-free survival (PFS) from a phase I study of crizotinib (PF-02341066) in ...
The Conversation

Genetic mutations can be benign or cancerous – a new method to differentiate between them could lead to better treatments

Ryan Layer does not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and has disclosed no relevant affiliations beyond their ...
Medscape

HIV: Failed Viral Suppression in CAB/RPV Linked to Three Risk Factors

A body mass index (BMI) ≥30 kg/m 2, rilpivirine resistance–associated mutations, and the HIV-1 subtype A6/A1 can raise a person's risk for confirmed virologic failure (CVF) of long-acting cabotegravir ...
EurekAlert!

New biological route for swine flu to human infections

A new biological pathway by which the H1N1 flu virus can make the jump from swine to humans has been discovered by researchers with the U.S. Department of Energy's Lawrence Berkeley National ...