While other research groups had successfully added RAG1 to patient HSC, they were unable to properly ... They transplanted these edited human cells into SCID-model mice and found that B and T cells ...

Khiong et al. identified a spontaneous mutation (Arg972Gln) in mouse RAG1, which is identical to a mutation in a patient with Omenn syndrome. So, both groups studied these mice to determine ...

The authors generated mutant mice in which the RAG proteins could interact ... as well as RNA polymerase II occupancy. Binding of RAG1 and RAG2 could occur independently of each other, suggesting ...