The authors generated mutant mice in which the RAG proteins could ... but not at other regions of the Tcrβ locus in pro-T cells. Of note, RAG binding at these sites in the Igh and Tcrβ loci ...

5 However, RAG-1 mutations can occur at several different sites ... They transplanted these edited human cells into SCID-model mice and found that B and T cells spiked to levels similar to those seen ...

Rapid cloning of the effector T cell, sequencing of its ... of hemolytic complement) make NOD mice congenic for additional immunodeficiency genes (scid and rag ) ideal hosts for carrying human ...