A T-cell therapy developed by Orca Bio, a private biotech company, significantly reduced the risk of a debilitating immune ...

like sickle cell disease and β-thalassemia. 5 However, RAG-1 mutations can occur at several different sites within the gene, so base editing wouldn’t cover every type of mutation. Instead, the ...

The authors generated mutant mice in which the RAG proteins could interact with and bind to DNA normally without initiating V(D)J recombination and assessed RAG protein binding, as well as the ...

Astellas is to work with UK biotech Adaptimmune Therapeutics to develop allogeneic ‘off-the-shelf’ T-cell therapies for cancer. The Japanese pharma said its wholly-owned subsidiary Universal ...