(A) Suppressor tRNA readthrough strategy. Natural tRNAs with engineered anticodons are charged with canonical amino acids to enable readthrough of the premature termination codon (PTC). (B) Unnatural ...

Deep in the protein translation machinery are cogs known as transfer RNAs, or tRNAs. Actually, they may be more than mere cogs, say scientists at the University of Chicago. Like other components of ...

A groundbreaking study has shed light on the critical role of a tRNA methylation enzyme, TRMT10A, in supporting brain function. The findings reveal how the absence of TRMT10A leads to a reduction in ...

Neurodegenerative diseases are commonly adult-onset conditions characterized by degeneration of specific neuronal populations. Familial forms are caused by mutations in single genes, but most patients ...

Daisuke Kiga, Kensaku Sakamoto, Koichiro Kodama, Takanori Kigawa, Takayoshi Matsuda, Takashi Yabuki, Mikako Shirouzu, Yoko Harada, Hiroshi Nakayama, Koji Takio, Yoshinori Hasegawa, Yaeta Endo, Ichiro ...

Translocation: The ribosome moves one codon down the mRNA. The tRNA in the A site moves to the P site, the tRNA in the P site moves to the E site (exit site) and is released, and the A site is now ...

In cap-dependent translation initiation, the open reading frame (ORF) of mRNA is established by the placement of the AUG start codon and initiator tRNA in the ribosomal peptidyl (P) site. Internal ...

A new study of transfer RNA, a molecule that delivers amino acids to the protein-building machinery of the cell, challenges long-held ideas about the evolutionary history of protein synthesis. A new ...

tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...

Instead of fixing one of the many genes that can be mutated, the technique addresses a type of mutation they share, a stop ...