This study presents a valuable finding on the direct cytotoxic effects of DuoHexaBody-CD37 in diffuse large B-cell lymphoma, mediated via SHP-1 activation and antibody clustering, independent of ...

Therefore, the challenge for future kinase-directed drug discovery is to dissect the affected pathways and verify the downstream effector kinases. The multitude and diversity of mutations detected ...

A Series in The Lancet Neurology provides state-of-the-art reviews covering clinical and scientific evidence on the four most common genetic subtypes of amyotrophic lateral sclerosis (ALS), caused by ...

[23] Estrogens are known to drive physiological selection of Th1 or Th2 pathways. A perturbation in immune receptor signaling may underlie the increase in autoimmune phenomena in the elderly ...

Panelists discuss how immunoglobulin A (IgA) nephropathy treatment has evolved to include supportive care with optimized blood pressure control and renin-angiotensin system blockade as first-line ...

An early evaluation revealed attempts at “reward hacking” in o3 and strong task-solving abilities in o4-mini.