Genome editing has advanced at a rapid pace with promising results for treating genetic conditions-but there is always room for improvement.

CRISPR-Cas9 genome editing exploits the CRISPR-Cas ... Using a genome-wide CRISPR knock-out screen, the authors defined the repertoire of genes that are required for proerythroblast survival ...

Latest study leverages new constructs for nuclear localization signal (NLS) sequences to improve editing efficiency in human ...

Various models have been generated using the CRISPR/Cas9 technology, which displaying a more accurate disease phenotype in various cell lines, such as stem cells, iPSCs, and transgenic animals ...

This fundamental study further validates DNAH12 as a causative gene for asthenoteratozoospermia and male infertility in both humans and mice. Compelling evidence supports the notion that DNAH12 is ...

To strengthen the capacity of NK lymphocytes to eliminate tumors, researchers used CRISPR/Cas9, a genetic editing ... The results, both in vitro and in mice models, demonstrate that the ...

The development of precise and efficient delivery systems is pivotal for advancing CRISPR/Cas9 gene-editing technologies, particularly for therapeutic applications. Engineered metal–organic frameworks ...

Scientists hoping to treat immunodeficiencies using gene therapy have found a way to edit stem cells in mice without disrupting gene regulation ... interspaced short palindromic repeats (CRISPR-Cas9) ...

Glaucoma is a leading cause of irreversible blindness. In this study, we investigated if transplanted stem cells are able to rescue a glaucoma mouse model with transgenic myocilin Y437H mutation and ...

Here, we characterize systemic insulin resistance, anxiety-related behavior and memory in 15 to 20 weeks old Wild-Type (WT), Tau knockout (TauKO) and a distinct hTau mouse model consisting of tau ...