Addressing chemo-resistant homologous recombination-proficient (HRP ... Here, we explore HDAC3 genetic depletion/knockout (KO) and precision targeting using HDAC-PROTACs in five cell lines. Methods: ...

As primary spermatocytes of double knockout mice stop their differentiation ... especially DNA synapse, homologous recombination and DNA repair, (2) genes associated with cellular stress and apoptosis ...

The gene knockout technique could be scaled up and potentially used to manage the invasive species. The relentless swarm of cane toads (Rhinella marina) conquering Australia may soon be hobbled by ...

During meiosis, at least one crossover is selectively generated per pair of homologous chromosomes through ... S100PBP as a key modulator of both XY and autosomal recombination in mice.

To determine if homologous recombination deficiency (HRD ... Unsupervised analysis was performed to identify genes in HRD-high (sum score greater than or equal to 42) and HRD-low samples (sum score ...

Those edited toads could then produce a clutch of tadpoles that have the gene knockout, but could not breed. "If we could raise those young toads to adult size and breed them then we would have ...

The evidence for the authors' claims is convincing, combining state of the art conditional gene deletion in the mouse lens with histological and molecular approaches. This work should be of great ...

Background: The literature on the role of pleomorphic adenoma gene 1 (PLAG1) in malignant tumors is limited ... loss of heterozygosity (LOH), microsatellite instability (MSI), and homologous ...

School of Food Sciences and Engineering, South China University of Technology, Guangzhou, China In this study, we applied TurboID to explore the directly interacting proteins of cyanobacterial S2P. In ...