With age, tanycytes showed reduced expression of genes involved ... ‘feeding neuropeptides’ AGRP and NPY, or express leptin and GLP-1 receptors that are known to be important regulators ...

Tissue-specific expression of precursor proteins was mapped ... independent of GLP-1, leptin, and MC4R signaling. Pharmacokinetic analysis showed that BRP is rapidly cleared, with peak plasma ...

These ideas include the inflammation-induced activation of the kynurenine pathway and its role in feeding and metabolism by activation of the aryl hydrocarbon receptor (AHR ... on different forms of ...

or leptin receptor deficiency. The randomized, double-blind, placebo-controlled phase 3 TRANSCEND trial (ClinicalTrials.gov Identifier: NCT05774756) evaluated the efficacy and safety of ...

Long-lived IgG-producing plasma cells can be targeted by means of their expression of CD38 ... of therapeutics that disable the neonatal Fc receptor (FcRn), which protects IgG from degradation ...

Emerging evidence indicates that leptin promotes placental and endothelial dysfunction via diverse pathways involving endothelin-1, mineralocorticoid receptor activation, angiogenic peptides, and ...

Obesity and Metabolism Laboratory, The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, Israel Laboratory of Nano Delivery ...

To this end, it is worth noting that FPR2 cell surface expression was unchanged even after two weeks of compound administration; the lack of prolonged disappearance of the receptor could be due to the ...

Department of Physiology and Cell Biology, The Ohio State University College of Medicine Wexner Medical Center, Columbus. (N.L., P.J.M., V.F.) Bob and Corrine Frick Center for Heart Failure and ...