It is a problem with the alternative pathway of complement. It starts with either a genetic abnormality—that's the minority of patients—or autoimmunity to the alternative pathway. Again ...

In patients with C3G, overactivation of the alternative complement pathway leads to C3 cleavage within the glomeruli resulting in C3 deposition and inflammation. By binding to factor B ...

Dianthus Therapeutics targets severe autoimmune diseases with DNTH103. Read more on DNTH's promise amid competitive ...

Thromboplastic substances released by hemolysis and the activation of complement lead to activation of the extrinsic pathway of the coagulation cascade, contributing to DIC. DIC is seen in ...

AChR blocking and antigenic modulation trigger complement activation in MG. In addition to the classical pathway, the role of the activated alternative pathway in MG pathology requires further ...

H) Versican gene expression in PASMC stimulated 24h with active complement components C3a or C5a ... high-affinity integrin receptors, which activate alternative downstream signaling pathways (Nguyen ...