A Ph.D. student in biomolecular engineering at the University of California, Santa Cruz, has built a software program ...

Advanced forms of CRISPR allow researchers to rapidly screen diseased versus normal cells, finding targets for gene editing. Scientists used to spend years and "tons of money" breeding mice that ...

CRISPR screen identifies EIF3D as critical regulator of stem cell pluripotency maintenance. Story by Science X staff • 11h. A team of CiRA researchers has uncovered the crucial role of EIF3D—a ...

Li M et al. Genome-wide CRISPR-KO Screen Uncovers mTORC1-Mediated Gsk3 Regulation in Naive Pluripotency Maintenance and Dissolution. Cell Rep . 2018; 24: 489–502. Doench JG.

CRISPR screens can be performed either with a pooled approach, where all the cells are in large plates, or an arrayed approach, where each well in a multiwell plate contains a different target.

But a new CRISPR screen method developed at Scripps Research has the potential to uncover new therapeutic targets and treatments for these conditions. The method, ...

Using a new CRISPR-based methodology for modulating DNA structure to enact epigenetic control over specific genes, a team of researchers has identified a “master regulator” gene capable of improving T ...