Drugs that bind to and activate the receptors for the hormones GLP-1 and GIP are effective in the treatment of obesity and ...

Laboratory of Medicinal Chemistry, Faculty of Pharmacy and Food Sciences and Institute of Biomedicine (IBUB), Universitat de Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain ...

Emerging evidence indicates that leptin promotes placental and endothelial dysfunction via diverse pathways involving endothelin-1, mineralocorticoid receptor activation, angiogenic peptides, and ...

To this end, it is worth noting that FPR2 cell surface expression was unchanged even after two weeks of compound administration; the lack of prolonged disappearance of the receptor could be due to the ...

1Children’s Research Institute and the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas. 10Howard Hughes Medical Institute, UT Southwestern Medical Center, ...

Palatin Technologies Inc. has obtained U.S. orphan drug designation for PL-7737 for leptin receptor (LEPR) deficiency, including obesity caused by this condition. BioWorld Science Regulatory Endocrine ...

The 5-hydroxytryptamine 2C receptor (5-HTR2C) is a class G protein-coupled receptor ... and its interaction with other metabolic hormones, such as leptin, ghrelin, insulin, and estrogens. Moreover, ...

Both treatment groups (saline and leptin) were aggregated together for downstream analysis ... Clusters were annotated based on previous literature, and differential gene expression test was performed ...

Here, we investigated the expression of leptin in stomach biopsies ... leptin-deficient ob/ob mice and intestine-specific leptin receptor isoform B-deficient mice. These data demonstrate that ...

ARBs are effective in controlling hypertension and associated CVD risks beyond BP lowering by blocking the binding of angiotensin II to the AT 1 receptor. Therefore, further studies are warranted to ...