The ability of the Geneva homologous recombination deficiency (HRD) test to predict progression-free survival (PFS) in patients with high-grade ovarian cancer treated with poly (ADP-ribose) polymerase ...

The Association for Molecular Pathology announced the publication of best practice recommendations for clinical laboratories developing and performing homologous recombination deficiency (HRD ...

Genome rearrangements often result from non-allelic homologous recombination (NAHR) between repetitive DNA elements dispersed throughout the genome. Here we systematically analyze NAHR between Ty ...

These Sgs1- and Exo1-independent rearrangements depend partially upon a Rad51-mediated homologous recombination pathway. Furthermore, without resection a robust cell cycle arrest is not activated, ...

This study investigates the role of Alus in Non-allelic Homologous Recombination (NAHR), one of the primary pathways for CNV formation. Additionally, a multi-modal Convolutional Neural Network (CNN) ...

These clusters are associated with non-allelic homologous recombination (NAHR) which is among the commonest mechanisms underpinning CNVs. The BP1-BP5 segment includes the Prader-Willi Syndrome (PWS) ...

Strengths: Their results are especially striking in that the "simplest" mechanism of GAP1 amplification-non-allelic homologous recombination between the flanking Ty-LTR elements is not the most common ...

3.4 Non-allelic homologous recombination The NAHR produces SVs when a genomic segment exhibits high sequence similarity to a non-allelic locus (13). This recombination can lead to the duplication of ...

Post 'Bonobos Prove Race Exists' On Amerika.org realist conservative blog ...

The researchers identified several mechanisms, but one stands out: non-allelic homologous recombination, or NAHR. Think of it as nature’s way of accidentally duplicating recipe cards – sometimes you ...