A randomized, double-blind, placebo-controlled crossover design was used, with subjects receiving 300 mg of pregabalin combined with 3 and 7 mg of morphine, morphine only, pregabalin only, or a double ...

FIGURE 1. Dose regimen of the phase I omadacycline trial. For intravenous 100 mg group and oral 300 mg group, both had single dose and multiple dose administration, and the washout period was 7 days.