Northwestern Medicine scientists have discovered how molecular "traffic controllers" in cells influence aging and cellular senescence—a state where cells stop dividing but remain metabolically active.

With a new study in the journal Cell, researchers at Stanford University and Stockholm University have contributed to increased knowledge about gene regulation in human cells. How genes are turned on ...

Background: Pulmonary Arterial Hypertension (PAH) is a rare, progressive lung disease with limited treatment options. Loss of BMPR2 expression is a well-established contributor to PAH pathogenesis.

On Wednesday afternoon, Haifan Lin, the director of the Yale Stem Cell Center, discussed his innovative research findings in stem cell gene expression and regulation at Brown’s 2025 Mac V. Edds ...

“This is the first detailed study of how and where ORC regulates epigenetics and gene expression in human cells,” said Anindya Dutta, Ph.D., leader of the study and chair of the University of Alabama ...

This is the first detailed study of how and where ORC subunits regulate epigenetics and gene expression in human cells. “This is the first detailed study of how and where ORC regulates epigenetics and ...

Origin-recognition complex, or ORC, plays an unexpectedly broad role in the regulation of human cell gene expression, according to a study in the journal Cell Reports. This is the first detailed study ...

Sequence motifs and cleavage site specificity of DCL1 and other RNase III enzymes. (a) The GHR motifs define the DCL1 cleavage site. (b) Sequence motifs recognized by DCL1, Dicer, and Drosha, with ...

A surprising discovery shows that seemingly disordered gene-regulating proteins rely on a structured partner to function. This hidden order could have major implications for understanding gene control ...

Summary: New research has identified the gene Egr-1 as a critical regulator of immune balance, offering hope for autoimmune disease therapies. In a mouse model of multiple sclerosis, loss of Egr-1 led ...