RAG-1 −/− mice treated with caspase inhibitors did ... which showed that administration of apoptosis-resistant T cells replicated the survival benefit of caspase inhibitors.

Assembly of antigen-specific T cell and B cell receptors occurs through V(D ... cells such as ILC2s are affected by RAG remains unclear. We find that in RAG-deficient mice, ILC2 populations expand and ...

The effect of VNS on intestinal inflammation and transit was investigated in wild-type, splenic denervated and Rag-1 knockout mice ... splenic denervated and T-cell-deficient mice. In contrast, VNS is ...

T cell therapy called AIC100, which targets the ICAM-1 protein, demonstrated encouraging responses and an acceptable safety profile in patients with two types of advanced thyroid cancer, according to ...

Cold' tumors are resistant to common immunotherapies. Researchers have uncovered a master regulator that can be manipulated to prevent tumor growth in mice.

Removing EPO signaling in mouse liver tumors leads to tumor regression along with sensitivity to immunotherapy.

while mice with these cells did not. An analysis of the gut immune cells found an imbalance among the T cells that trigger versus dampen immune responses to food particles in the allergic mice ...

A protein identified nearly 40 years ago for its ability to stimulate the production of red blood cells plays a surprising, ...

Researchers found a way to extend the lifespan of mice, but can we use the same trick to extend the human lifespan?

Renier Brentjens, MD, PhD, one of the pioneers in the development of chimeric antigen receptor (CAR) T-cell therapy, is poised to see the technology take its next big leap, with researchers ...

The scientists showed that, right at the onset of mild illness, the body also produces special T cells previously known only from chronic, severe infections and tumors. Even in the case of ...