During his appearance on the " Armchair Expert " podcast on Monday, the "Frozen" actor opened up about taking weight loss medication. "I’m on a GLP-1," Gad revealed during the conversation with Dax Shepard and Monica Padma, noting that this is his first time speaking out publicly about the topic.

The newest weight-loss drugs, Wegovy and Zepbound, are incredibly popular. But doctors are still learning about all of the ways they affect the body—both helpful and harmful—beyond reducing weight. In report published in Nature Medicine,

If you’re in a calorie deficit – either from dieting or while taking a weight loss drug – these exercises help direct your body to burn more fat instead and hang on to muscle. There’s also a beneficial metabolic effect: muscle tissue burns more calories at rest than fat, which can support long-term weight management.

Websites selling compounded versions of popular weight-loss drugs from Novo Nordisk and Eli Lilly to U.S. consumers often do not inform patients of the risks associated with these medicines, according to a research letter published on Friday.

Some outcomes, like reduced risk of cardiovascular disease and increased chance of nausea, were expected. But others took researchers by surprise.

Josh Gad has opened up for the first time about using GLP-1 medication for weight loss and his seesaw experience with the positive and negative side effects.