BCL6 is a regulator of SOCS2, so less BCL6 leads to less SOCS2. At normal levels, this allows BCL6 to control how much SOCS2 is expressed, and therefore, how much IGF1 is made.

BCL6 regulates SOCS2, so a decrease in BCL6 leads to a drop in SOCS2. Under normal conditions, BCL6 ensures proper SOCS2 expression, which, in turn, controls the production of IGF1.

BCL6 is a regulator of SOCS2, so less BCL6 leads to less SOCS2. At normal levels, this allows BCL6 to control how much SOCS2 is expressed and therefore how much IGF1 is made.

BCL6 appears to be particularly active when your body releases certain hunger hormones showing its role in preserving muscle mass during periods of caloric restriction.

BCL6 is a transcriptional repressor that has important functions in lymphocyte differentiation and lymphomagenesis, but there have been no reports of BCL6 expression in gastric cancers. In the ...

The BCL6 proto-oncogene encodes a transcriptional repressor that is required for germinal center formation and has been linked to lymphomagenesis. BCL6 functions by directly binding to specific ...

BCL6 is a regulator of SOCS2, so less BCL6 leads to less SOCS2. At normal levels, this allows BCL6 to control how much SOCS2 is expressed and therefore how much IGF1 is made.

BCL6 Discovery Sparks Hope for Muscle-Preserving Therapies “We are excited to reveal BCL6’s important role in maintaining muscle mass,” says first author of the study Hunter Wang, a ...

The gene is Bcl6, which the team found plays the crucial role in differentiating a naïve T cell into a T follicular helper cell (Tfh). "Tfh cells were first noticed in structures called germinal ...

Previous studies demonstrated that women with abnormal BCL6 expression (Positive ReceptivaDx™ result) had less than a 11% chance of success in the IVF setting if left untreated. This new study ...

image: BCL6 knock-out in a DLBCL xenograft induces tumor stasis. Tumor xenografts were established in C.B-17 SCID mice by subcutaneous injection of inducible SU-DHL-4 Cas9 BCL6 and control sgRNA ...

In this particular case, it turned on the apoptosis gene that BCL6 normally keeps turned off. By turning it back on, the researchers found that they could self-destruct cancer cells.