013144 - Aim2 KO Strain Details - The Jackson Laboratory
These mice may be useful for studying the innate immune system's response to bacterial and viral infection. Aim2 senses radiation-induced DNA damage in the nucleus to mediate …
Conditional knockout of AIM2 in microglia ameliorates synaptic …
Conditional knockout of microglial AIM2 rescued cognitive and synaptic dysfunction in AD mice. Excessive microglial phagocytosis activity of synapses was decreased after knockout of …
AIM2 regulates autophagy to mitigate oxidative stress in aged mice …
Mar 1, 2024 · In this study, we unveil AIM2’s novel function as a negative regulator in the pathogenesis of APAP-induced liver damage in aged mice, independently of inflammasome …
The AIM2 inflammasome is essential for host defense against …
Mar 28, 2010 · Here we investigate the role of AIM2 in vivo by generating mice lacking Aim2. We show that AIM2 regulated caspase-1-dependent processing of pro-IL-1β and pro-IL-18 in …
AIM2 inflammasome mediates hallmark neuropathological alterations …
Dec 9, 2020 · Moreover, in AIM2 knockout mice we observed attenuated inflammasome-mediated production of proinflammatory cytokines, apoptosis, and pyroptosis, as well as resistance to …
Deletion of the Inflammasome Sensor Aim2 Mitigates Aβ
Knockout of Nlrp3, a gene encoding an inflammasome sensor, has been shown to ameliorate AD pathology in a mouse model. Because AIM2 is the most dominant inflammasome sensor …
Role of the AIM2 Inflammasome in Cancer: Potential Therapeutic ...
The pharmacological inhibition of Akt reduced the tumor load in AIM2 knockout mice, suggesting that Akt inhibitors could be used to treat AIM2-deficient human cancers. Very recently, Pu et …
Conditional knockout of AIM2 in microglia ameliorates synaptic ...
C57BL/6 mice injected with AIM2 overexpression lentivirus and conditional knockout of microglial AIM2 mice were used to confirm the function of AIM2 in AD. Cognitive functions were …
AIM2 controls microglial inflammation to prevent experimental ...
In this study, we found that AIM2 negatively regulates the pathogenesis of EAE independent of inflammasome activation. AIM2 deficiency enhanced microglia activation and infiltration of …
Stroke Literature Synopses (Preclinical) | Stroke - AHA/ASA Journals
Nov 25, 2024 · Poststroke, Aim2 knockout mice experienced improved cognitive function, as well as decreased infarct volume of the hippocampus and decreased levels of GSDMD at 7 days …