The JAK-STAT signaling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death, and tumor formation.

The Janus kinase (JAK)–signal transducer and activator of transcrip-tion (STAT) pathway relays signals from approximately 60 extracellu-lar cytokines and hormones through the cell …

Feb 23, 2023 · In this review, we discuss the role of the JAK/STAT pathway in mechanistic signaling, disease progression, immune environment, and therapeutic targets.

Aug 1, 2025 · Among these sophisticated pathways, JAK-STAT signaling stands out as a fundamental mechanism. This pathway acts as a rapid conduit, transmitting external signals …

JAK-STAT Signaling Pathway - an overview - ScienceDirect

Jan 8, 2025 · In this blog post, we will explore the key components of the JAK-STAT pathway, its role in various diseases, and how it is targeted for therapeutic purposes, particularly in cancer …

The JAK-STAT signaling pathway transmits information from extracellular chemical signals to the nucleus resulting in DNA transcription and expression of genes involved in immunity, …

Apr 30, 2025 · The JAK-STAT pathway provides a direct route for transmitting signals from cell surface receptors to the nucleus. When cytokines or growth factors bind to their receptors, …

JAK/STAT is a pivotal signal transduction pathway driving cellular responses such as proliferation, migration, differentiation, angiogenesis, and apoptosis. This pathway is central to homeostasis …

The JAK-STAT signaling pathway is a crucial mechanism in cellular communication, particularly in response to cytokines like erythropoietin (EPO). This pathway unfolds in seven distinct steps, …