Naltrexone is at the heart of the Sinclair Method (TSM) for Alcoholism. When you take Naltrexone prior to drinking, it blocks endorphins, the naturally occurring opiates in the brain, from being …

Dec 21, 2025 · It relies on medication to make drinking feel less pleasurable, reducing the urge to drink and making it easier for people to limit their consumption. This approach was introduced …

Sinclair confirmed his hypothesis with clinical studies in Finland, and found that targeted naltrexone could not only help people drink less, but over time, it could help them lose the …

5 days ago · FDA-approved naltrexone can help reduce alcohol cravings and binge drinking by blocking brain reward centers. Learn how this prescription medication works.

Dec 19, 2025 · The Sinclair Method for alcoholism is an alternative, evidence-based approach to abstinence involving the alcohol treatment medication, naltrexone, to reduce alcohol …

Jun 17, 2025 · What Is the Sinclair Method? Developed by neurobiologist Dr. John D. Sinclair in the 1980s, the protocol pairs continued drinking with targeted doses of naltrexone 50 mg (or …

Feb 5, 2025 · In this comprehensive guide, we will explore the Sinclair Method from every angle—its origins, the science behind it, how naltrexone interacts with the body, step-by-step …

Sep 24, 2024 · Naltrexone is a prescription drug used to treat opioid use disorder and alcohol use disorder. Learn how to lower long-term costs and more.

However, increased awareness and use of this evidence-based medication with the Sinclair Method is offering hope for anyone drinking more than they would like. Naltrexone is an opioid …

Jan 5, 2026 · Current drugs shortage notification for Naltrexone Hydrochloride Tablet including reason for shortage, estimated resupply dates, and alternative drug therapy if available.