Bcl-6 (B-cell lymphoma 6) is a protein that in humans is encoded by the BCL6 gene. BCL6 is a master transcription factor for regulation of T follicular helper cells (T FH cells) proliferation. [5] BCL6 has three evolutionary conserved structural domains. [6]

Dec 24, 2024 · BCL6 (BCL6 Transcription Repressor) is a Protein Coding gene. Diseases associated with BCL6 include Intravascular Large B-Cell Lymphoma and High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit. Among its related pathways are Gene expression (Transcription) and Cytokine Signaling in Immune system.

Dec 2, 2022 · B-cell lymphoma 6 (BCL6) is a protooncogene in adult and pediatric cancers, first identified in diffuse large B-cell lymphoma (DLBCL) where it acts as a repressor of the tumor suppressor TP53, conferring survival, protection, and maintenance of lymphoma cells.

B cell lymphoma 6 (BCL6) is a conserved multi-domain protein that functions principally as a transcriptional repressor. This protein regulates many pivotal aspects of immune cell development and function. BCL6 is critical for germinal center (GC) ...

BCL6 is a transcriptional repressor which has emerged as a critical regulator of germinal centers (GC), the sites where B cells are selected based on the production of antibodies with high affinity for the antigen.

Jan 23, 2025 · To determine whether BCL6 was involved in muscle maintenance, the team compared mice with and without functional BCL6 proteins. Mice lacking BCL6 had 40% less muscle mass than their healthy counterparts, and the muscle they did have was compromised both in structure and function. However, when the researchers increased the …

BCL6 is required for GC B-cells to proliferate and tolerate the DNA damage that occurs as a byproduct of this process of immunoglobulin affinity maturation [1].

Dec 2, 2022 · B-cell lymphoma 6 (BCL6) is a protooncogene in adult and pediatric cancers, first identified in diffuse large B-cell lymphoma (DLBCL) where it acts as a repressor of the tumor suppressor TP53, conferring survival, protection, and maintenance of lymphoma cells.

Aug 15, 2013 · Elemento, Melnick, and colleagues examine mechanisms by which the BCL6 transcriptional repressor mediates its critical survival and proliferation functions in B cell lymphomas and germinal center B cells. BCL6 regulates one set of genes by forming hybrid Polycomb/HDAC promoter complexes with SMRT/NCOR and BCOR corepressors.

B cell lymphoma 6 (BCL6) is a transcriptional repressor critical for the development and maintenance of germinal centers (GCs), which are required for generation of an effective humoral immune response.